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SaeidAbroun

 

 SAEID ABROUN

Cancer researcher

 

Personal:

 

Name: SAEID

Sure name: ABROUN     

Birth: Aug 17 1961

Marital Status: Married 

Nationality: Iranian

Address: Dept. of Cell Bio-Signal Analysis,

Graduate School of Medicine ,Yamaguchi University.

1-1-1Minami, Kogoshi, Ube, Yamaguchi, 755-8505. Japan

Tel: +81 836 22 2236  

Fax: +81 836 22 2237     

E-mail: a010ep@yamaguchi-u.ac.jp 

  abroun_s@yahoo.co.uk,

 

 

Education:   

 

2004.03:  Ph.D. in Immunohematology. Department of Immunohematology,

(Myeloma Study Group). Graduate School of Medicine.

Yamaguchi University, Japan.

1988.10:  M.Sc. in Hematology and blood bank.

Dept. of hematology and blood bank. School of Medical Sciences.

Tarbiat Modarres University (TMU). Tehran, IR.Iran 

1995.02   B.Sc in Biology. Payame Nor University. Tehran. IR.IRAN

1987.10   Medical Lab. Technician.

Shahid Beheshty University, School of Medical Science. Tehran. IR.Iran

 

Experience:

    

Now:  Researcher in Dept. of Cell Bio-Signal Analysis, Graduate School of Medicine, Yamaguchi Uni.

2004.10- 2006.09:  Postdoctoral researcher fellow under the JSPS postdoctoral fellowship in Dept. of Cell Bio-Signal Analysis (Myeloma Study Group) Graduate school of medicine.

Yamaguchi University. Japan.              

2004.4-2004.9   Foreign scientist researcher in Dept. of Immunohematology,

Graduate school of medicine. Yamaguchi University. Japan

2000.04-2004.03: Assistant researcher and assistant teacher in Dept. of Immunohematology,

Graduate school of medicine. Yamaguchi University. Japan

1987.10-1999.11 Technician ,Chief technician, of Histology Lab. and Manager of Electron microscope Lab. Dept. of Anatomy sciences. School of Medical Sciences. TMU. Tehran. Iran 

                           

Research Work:  

2004. 4- present:  

- The role of Stromal Derived Factor -1and Galectin-1 on biology of Myeloma cells.

- Establish in vitro culture system to keep primary myeloma cell survive in-vitro.

- The mechanism of NF-kB activation in primary myeloma cells

Collaborate in:  - The mechanism of NF-kB activation in and myeloma cell lines

- Induction of trans differentiation of myeloma cells.

- The mechanism of growth suppression of PPARb in myeloma cell.                          

2000.4- 2004.3: 

-The new role of IL-6 on myeloma cell proliferation.

-Role of CD45 on cell surface to increased susceptibility to apoptosis.

-DHEA as inhibitor of myeloma cell proliferation.

-Chin’s traditional drags suppres proliferation and induce apoptosis in myeloma 

- Roles of lipid raft on cell response to cytokines.

- FGFR3 and enhanced cell response to cytokine (IL-6). 

1995- 1998     

-The ultrastructure of macrophage in smoker and non-smoker. 

Dept. of hematology and blood bank. School of Medical Sciences. TMU, Iran

 

Interest subjects:

Role of NF-kB in cell differentiation and cell proliferation.

 

Skills:

- Most of usuall Molecular  Biology technique (cell culture, Immunopercipitation, western blot, ELIZA, RT-PCR, Real time PCR)

- Transmission and Scan Electron Microscopic techniques.

- Immunohistochemistry.

- Confocal laser microscope.

- FACS.

- EMSA.

- Gene constract and transfection.

 

Teaching: (1994-1999)

Hematology and blood banking to BSc students.

Practice histology and embryology to BSc students.

Advance histology technique to MSc Students.

Practice electron microscopic technique to PhD Students.

 

Award:

Japan Society for the promotion of Sciences Award (2004) for postdoctoral grant

Shahid Beheshty University. Excellent Graduate student.

 

Membership:

American Society of Hematology

Japanese Society of Hematology

 

PUBLICATIONS:

Full Paper Published in International  Juornals

1-Ken-Ichro Otsuyama, Zi Ma, Saeid Abroun. Amin J, Shamsasenjan K, Asoku H, Kawano M.M.PPARb- Mediated suppression ofBaicalin and Dexamethasone in human myeloma cells. 2006; Leukemia in press

2-Xu Zheng, Saeid Abroun, Ken-ichiro Otsuyama, Hideki Asaoka, Michio M. Kawano. Hetrogeneous expression of CD32 and CD32-mediated growth suppression in human myeloma cells. Haematologica. 2006; 91(7):920-928 

3-Liu S, Ishikawa H, Tsuyama N, Li FJ, Abroun S, Otsuyama K,  Zheng X, Ma Z, Maki Y, Iqbal MS, Obata M, Kawano MM. Increased susceptibility to apoptosis in CD45(+) myeloma cells accompanied by the increased expression of VDAC1. Oncogene. 2006;25(3):419-29 

4Ishikawa H, Tsuyama N, Liu S, Abroun S, Li FJ, Otsuyama K,  Zheng X, Ma Z, Maki Y, Iqbal MS, Obata M, Kawano MM. Accelerated proliferation of myeloma cells by interleukin-6 cooperating with fibroblast growth factor receptor 3-mediated signals. Oncogene. 2005;24(41):6328-32

5-Liu S, Ishikawa H, Li FJ, Ma Z, Otsuyama K, Asaoku H, Abroun S, Zheng X, Tsuyama N, Obata M, Kawano MM. Dehydroepiandrosterone can inhibit the proliferation of myeloma cells and the interleukin-6 production of bone marrow mononuclear cells from patients with myeloma. Cancer Res. 2005;65(6):2269-76.

6-Ma Z, Otsuyama K, Liu S, Abroun S, Ishikawa H, Tsuyama N, Obata M, Li FJ, Zheng X, Maki Y, Miyamoto K, Kawano MM.Baicalein, A component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. Blood. 2005;105(8):3312-8.

7-Li FJ, Tsuyama N, Ishikawa H, Obata M, Abroun S, Liu S, Otsuyama K, Zheng X, Ma Z, Maki Y, Kawano MM.A rapid translocation of CD45RO but not CD45RA to lipid rafts in IL-6-induced proliferation in myeloma. Blood. 2005;105(8):3295-302.

8-Tsuyama N, Ishikawa H, Abroun S, Liu S, Li FJ, Otsuyama K, Zheng X, Obata M, Taniguchi O, Kawano MM. The regulatory mechanism of IL-6-dependImpact factor 1.67

9-Abroun S, Ishikawa H, Tsuyama N, Liu S, Li FJ, Otsuyama K, Zheng X, Obata M, Kawano MM. Receptor synergy of interleukin-6 (IL-6) and insulin-like growth factor-I in myeloma cells that highly express IL-6 receptor alpha Blood. 2004 Mar 15;103(6):2291-8. Epub 2003 Oct 30. Erratum in: Blood. 2004 Apr 15;103(8):2891.

10Ishikawa H, Tsuyama N, Abroun S, Liu S, Li FJ, Otsuyama K, Zheng X, Kawano MM. Interleukin-6, CD45 and the src-kinases in myeloma cell proliferation.Leuk Lymphoma. 2003 Sep;44(9):1477-81. Review.

11-Ishikawa H, Tsuyama N, Mahmoud MS, Fujii R, Abroun S, Liu S, Li FJ, Kawano MM. CD19 expression and growth inhibition of tumours in human multiple myeloma. Leuk Lymphoma. 2002 Mar;43(3):613-6. Review.

12-Ishikawa H, Tsuyama N, Abroun S, Liu S, Li FJ, Taniguchi O, Kawano MM. Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6. Blood. 2002 Mar 15;99(6):2172-8.

13-Ishikawa H, Mahmoud MS, Fujii R, Abroun S, Kawano MM. Proliferation of immature myeloma cells by interleukin-6 is associated with CD45 expression in human multiple myeloma. Leuk Lymphoma. 2000 Sep;39(1-2):51-5. Review.

 

 

Abstracts in the annual meeting of American Society of hematology (BLOOD Journal).

1-Saeid Abroun. Fu-Jun Li, Naohiro Tsuyama, Karim Shamsasenjan, Hideki Asaoku, Toshikazu Gondo, Michio M Kawano. Galectin-1 can support the survival of human myeloma cells in in vitro culture. BLOOD Suppl. 106:11; Nov.2005

2-Xu Zheng, Maged S.Mahmoud, Saeid Abroun, Hideki Asoaku, Michio M Kawano. The loss of CD19 in myeloma cells contributes to the escape from FCgRII-mediated growth suppression. BLOOD Suppl. 106:11; Nov.2005

3-Ken-Ichro Otsuyama, Zi Ma, Shangqin Liu, Saeid Abroun. Hideki Asoaku, Michio M Kawano. PPAR- Mediated suppression of the growth and survival in human myeloma cells counteracting NF-kB activity. BLOOD Suppl. 106:11; Nov.2005

4-Li F, Tsuyama N, Ishikawa H, Obata M, Abroun S, Liu S, , Otsuyama K, Zheng X, Ma Z, Maki Y, Kawano M.M. IL-6 induced CD45RO, RB translocation to lipid raftin myeloma cell. BLOOD Suppl. 104:11; Nov.2004

5-Liu S, Ishikawa H, Tsuyama N, Abroun S, Li F, Otsuyama K, Zheng X, Ma Z, Maki Y, Obata M, Kawano M.M. CD45 defines signaling thresholds critical for proliferation and apoptosis in myeloma cell. BLOOD Suppl. 104:11; Nov.2004

6-Otsuyama K, Ma Z, Liu S, Li F, Abroun S, Tsuyama N, Zheng X, Maki Y, Obata M, Ishikawa H, Kawano M.M. DHEA can inhibit the proliferation of myeloma cells and the IL-6 production of bone marrow mononuclear cells from the myeloma patients. BLOOD Suppl. 104:11; Nov.2004

7-Zheng X, Ishikawa H, Tsuyama N, Abroun S, Liu S, Li F, Otsuyama K, Ma Z, Maki Y, Obata M, Kawano M.M. Roles of CD19 molecules that suppress proliferation and induce apoptosis in human myeloma cells. BLOOD Suppl. 104:11; Nov.2004

8-Abroun S, Ishikawa H, Tsuyama N, Liu S, Li F, Otsuyama K, Zheng X, Obata M, M.M. Kawano. Receptor synergy of IL-6 and IGF-I in the IL-6Ra highly expressing myeloma cell. BLOOD Suppl. 102:11; 926a.Nov.2003

9-Zheng X, Ishikawa H, Tsuyama N, Abroun S, Liu S, Li F, Otsuyama K, Obata M, M.M. Kawano. Biological significance of loss of CD19 molecules in human myeloma cells. BLOOD Suppl. 102:11; 926a.Nov.2003

10-Liu S, Ishikawa H, Tsuyama N, Abroun S, Li F, Otsuyama K, Zheng X, Obata M, M.M. Kawano. CD45+myeloma cells accompanied by VDAC-1 expression are sensitive to apoptosis. BLOOD Suppl. 102:11; 926a.Nov.2003

11-Abroun S, Ishikawa H, Tsuyama N, Liu S, Li F, Otsuyama K, Zheng X, M.M. Kawano. Consequence of IL-6 receptor alpha overexpression on IL-6-induced signals in myeloma cells. BLOOD Suppl. 100:11; 607a.Nov.2002

12-Kawano MM, Ishikawa H, Tsuyama N, Abroun S, Liu S, Li FJ, Otsuyama K, Zheng X. Growth mechanism of human myeloma cells by interleukin-6. Int J Hematol. 2002 Aug;76 Suppl 1:329-33.

13-Ishikawa H, Tsuyama N, Liu S, Abroun S, Li F, Otsuyama K, Zheng X, M.M. Kawano. Proliferation of myeloma cells by IL-6 co-operated with FGFR3-Mediated signals. BLOOD Suppl. 100:11; 607a.Nov.2002

14-Abroun S, Ishikawa H, Tsuyama N, Liu S, Li F, M.M. Kawano. Insulin and IGF-I are survival factor for myeloma cell in vitro. BLOOD Suppl. 98:11; 639a.Nov.2001

15-Tsuyama N, Ishikawa H, Liu S, Abroun S, Li F, Otsuyama K, Zheng X, M.M. Kawano. The proliferation of MPC-1-,CD49-,CD45+ immature myeloma cell are strictly controlled by IL-6 in the SCID-hIL-6Tg mice. BLOOD Suppl. 98:11; 639a.Nov.2001

16-Ishikawa H, Abroun S, Tsuyama N, Liu S, Li F, M.M. Kawano. Implication of an inhibitory role of STAT1 for myeloma cell proliferation. BLOOD Suppl. 98:11; 639a.Nov.2001

17-Abroun S, Ishikawa H, Liu S, M.M. Kawano. Direct evidence of differentiation pathway form MPC-1- to MPC-1+ Myeloma cells by IL-6. BLOOD Suppl. 96:11;752a. Nov.2000

18-Ishikawa H, Abroun S, Liu S, M.M. Kawano. Role of SRC family kinase activity association with CD45 phosphates for myeloma cell proliferation by interleukin-6. BLOOD Suppl. 96:11;752a. Nov.2000

 

Published abstract in Journal of  Japanese Society of Hematology (by Japanese language).

 

1-      Saeid Abroun, Karim Shamsasenjan, Ken-Ichiro Otsuyama, Jakia Amin, Zi Ma, Michio Kawano. Galectin-1 supports the in vitro survival of primary myeloma cells. 68th Annual meeting of Japan society of Hematology and 48thAnnual meeting of Japan society of clinical hematology 2006.

2-      Zi Ma, Ken-Ichiro Otsuyama, Saeid Abroun,  Michio Kawano. Growth inhibitory mechanism of human myeloma cells by low molecular weight compound Baicalin. 68th Annual meeting of Japan society of Hematology and 48thAnnual meeting of Japan society of clinical hematology 2006.

3-      Karim Shamsasenjan, Shangqin Liu, Saeid Abroun, Ken-Ichiro Otsuyama, Jakia Amin, Zi Ma, Michio Kawano. The expression of CD33 in primary myeloma cells as well as human myeloma cell lines. 68th Annual meeting of Japan society of Hematology and 48thAnnual meeting of Japan society of clinical hematology 2006.

4-      The expression od CD56 combined with the neurnal cell markers or CD7 in human myeloma cell. Michio Kawano, Shangqin Liu, Karim Shamsasenjan, Saeid Abroun, Ken-Ichiro Otsuyama, Jakia Amin, Zi Ma,. 68th Annual meeting of Japan society of Hematology and 48thAnnual meeting of Japan society of clinical hematology 2006.

5-      Ken-Ichiro Otsuyama, Jakia Amin, Zi Ma, Saeid Abroun, Karim Shamsasenjan, Michio Kawano. The mechanism of PPAR beta-mediated suppression of proliferation on human myeloma cells. 68th Annual meeting of Japan society of Hematology and 48thAnnual meeting of Japan society of clinical hematology 2006.

6-      Jakia Amin, Ken-Ichiro Otsuyama,  Saeid Abroun, ,Zi Ma, , Karim Shamsasenjan, Michio Kawano.  The quantification of NF-kB and the mechanism of its constitutive expression in MM cells. 68th Annual meeting of Japan society of Hematology and 48thAnnual meeting of Japan society of clinical hematology 2006.

7-      Abroun S, Ishikawa H, Tsuyama N, Obata M, Liu S,, Li F, Otsuyama K, Zheng X, Ma Z, Maki Y, Iqbal MH. Kawano M.M. The biological effect of Stromal cell-derived factor (SDF)-1 alpha on myeloma cells. 67th Annual meeting of Japan society of Hematology and 47thAnnual meeting of Japan society of clinical hematology 2005.

8-      Ma Z, Otsuyama K, Liu S, Abroun S, Li F,  Zheng X , Maki Y, Tsuyama N, Obata M, Ishikawa H, Kawano M. Growth inhibitory mechanism of human myeloma cells by low molecular weight compound Baicalin. 67th Annual meeting of Japan society of Hematology and 47thAnnual meeting of Japan society of clinical hematology 2005.

9-      Otsuyama K, Liu S, Ma Z, Li F, Abroun S, Zheng X , Maki Y, Iqbal MH Tsuyama N, Obata M, Ishikawa H, Kawano M. Growth mechanism of human myeloma cells by PPAR beta: DHEA-induced growth suppression.67th Annual meeting of Japan society of Hematology and 47thAnnual meeting of Japan society of clinical hematology 2005.

10-  Maki Y, Obata M, Abroun S, Liu S, Li F, Otsuyama K, , Zheng X, Ma Z, Tsuyama N, Ishikawa H, Kawano M. Enforced expression of Pax-5 in myeloma cell lines suppresses their growth. 67th Annual meeting of Japan society of Hematology and 47thAnnual meeting of Japan society of clinical hematology 2005.

11-  Zheng X, Ishikawa H, , Abroun S, Li F, Otsuyama K, Liu S, Ma Z, Maki Y, Iqbal MH, T suyama N, Obata M, Kawano M.  Fc gamma RII-mediated growth inhibition is augmented by exogenous CD19 expression in human myeloma cells.67th Annual meeting of Japan society of Hematology and 47thA nnual meeting of Japan society of clinical hematology 2005. (Japanese)

12-  Otidsuyama K, Liu S, Ma Z, Abroun S, Tsuyama N, Li F, Zheng X, Maki Y, Obata M, Ishikawa H, Kawano M.M. The effect of Baicalin on suppress myeloma cell proliferation.103rdAnnual Scientific meting of Yamaguchi University. 2005.

13-  Abroun S, Ishikawa H, Tsuyama N, Liu S, Li F, Otsuyama K, Zheng X, Ma Z, Maki Y, Obata M, Kawano M.M. The biological effect and molecular mechanism of SDF-1a on myeloma cell. 103rd Annual Scientific meting of Yamaguchi University. 2005. (Japanese)

14-  Ma Z, Liu S, Otsuyama K, Abroun S, Li F, Zheng X, Maki Y, Obata M, Tsuyama N, Ishikawa H, Kawano M.M. The effect of Huang-Liang-Jie-Du-tang and Baicalein on the proliferation of myeloma cells. 66th Annual meeting of Japan society of Hematology and 46thAnnual meeting of Japan society of clinical hematology 2004.

15-  Obata M, Watanabe A, Maki Y, Tsuyama N, Abroun S, Liu S, Li F, Otsuyama K, Zheng X, Ma Z, Ishikawa H, Kawano M.M. 66th Annual meeting of Japan society of Hematology and 46thAnnual meeting of Japan society of clinical hematology 2004.

16-  Liu S, Ishikawa H, Tsuyama N, Li F, Abroun S, Otsuyama K, Zheng X, Ma Z, Maki Y, Obata M, Kawano M.M. Susceptibillity to apoptosis in CD45+ myeloma cells accompanied by the increased expression of VDAC-1. 66th Annual meeting of Japan society of Hematology and 46thAnnual meeting of Japan society of clinical hematology 2004.

17-  Li F, Tsuyama N, Ishikawa H, Obata M, Abroun S, Liu S, Otsuyama K, Zheng X, Ma Z, Maki Y, Kawano M.M. CD45 move to lipid raft after IL-6 stimulation in myeloma cells. 66th Annual meeting of Japan society of Hematology and 46thAnnual meeting of Japan society of clinical hematology 2004.

18-  Zheng X, Ishikawa H, Tsuyama N, Abroun S, Liu S, Li F, Otsuyama K, Ma Z, Maki Y, Obata M, Kawano M.M. Distinct effect of the enforced CD19 expression on the proliferation of CD45- and CD45+ U266. 66th Annual meeting of Japan society of Hematology and 46thAnnual meeting of Japan society of clinical hematology 2004.

19-  Tsuyama N, Li F, Ishikawa H, Obata M, Abroun S, Liu S, Otsuyama K, Zheng X, Ma Z, Maki Y, Kawano M.M. Correlation of IL-6Ra expression level and IL-6 responsive proliferation of myeloma cells. 66th Annual meeting of Japan society of Hematology and 46thAnnual meeting of Japan society of clinical hematology 2004.

20-  Otsuyama K, Liu S, Ma Z, Li F, Abroun S, Ishikawa H, Tsuyama N, Zheng X, Maki Y, Obata M, Kawano M.M. The effect of DHEA on the proliferation and IL-6 production of myeloma cells. 66th Annual meeting of Japan society of Hematology and 46thAnnual meeting of Japan society of clinical hematology 2004.

21-  Abroun S, Ishikawa H, Tsuyama N, Liu S, Li F, Otsuyama K, Zheng X, Ma Z, Maki Y, Obata M, Kawano M.M. Enhanced proliferation of human myeloma cell line NOP2 by SDF-1a.66th Annual meeting of Japan society of Hematology and 46thAnnual meeting of Japan society of clinical hematology 2004.

22-  Otsuyama K, Tsuyama N, Ishikawa H, Li F, Abroun S, Liu S, Zheng X, Kawano M.M. Identification of IL-6 inducible genes concerning with myeloma cell proliferation. 65th Annual meeting of Japan society of Hematology and 45thAnnual meeting of Japan society of clinical hematology 2003.

23-  Li F, Tsuyama N, Ishikawa H, Otsuyama K, Abroun S, Liu S, Zheng X, Kawano M.M. Fluorescent imaging analysis of IL-6 signal transduction molecules. 65th Annual meeting of Japan society of Hematology and 45thAnnual meeting of Japan society of clinical hematology 2003.

24-  Ishikawa H, Tsuyama N, Abroun S, Liu S, Li F, Otsuyama K, Zheng X, Kawano M.M. Monocyte or dendritic cell-likue phenotype of human myeloma cell line MSG-Y01. 65th Annual meting of Japan society of Hematology and 45thAnnual meeting of Japan society of clinical hematology 2003.

25-  Zheng X, Ishikawa H, Tsuyama N, Abroun S, Liu S, Li F, Otsuyama K, Kawano M.M. Effect of CD19 transgene expression on proliferation of CD45+ and CD45- U266 cells. 65th Annual meting of Japan society of Hematology and 45thAnnual meeting of Japan society of clinical hematology 2003.

26-  Liu S, Ishikawa H, Tsuyama N, Li F, Abroun S, Otsuyama K, Zheng X, Kawano M.M. Increased sensitivity in mitochondria-dependent apoptosis of CD45+ U266 cells. 65th Annual meting of Japan society of Hematology and 45thAnnual meeting of Japan society of clinical hematology 2003.

27-  Abroun S, Ishikawa H, Tsuyama N, Li F, Liu S, Otsuyama K, Zheng X, Kawano M.M. Activation of insulin/IGF-I receptor by IL-6a overexpression. 65th Annual meting of Japan society of Hematology and 45thAnnual meeting of Japan society of clinical hematology 2003.

28-  Ishikawa H, Tsuyama N, Abroun S, Liu S, Li F, Otsuyama K, Zheng X, Kawano M.M. Cooperation effect of IL-6 and FGF on myeloma cell proliferation.27th Annual myeloma meeting. 2002

29-  Abroun S, Ishikawa H, Tsuyama N, Li F, Liu S, Otsuyama K, Zheng X, Kawano M.M. IL-6 can support Myeloma cell proliferation. 27th Annual myeloma meeting. 2002

30-  Li F, Tsuyama N, Ishikawa H, Otsuyama K, Abroun S, Liu S, Zheng X, Kawano M.M. GFP-Tag used for IL-6 signals. 99th Annual Scientific meting of Yamaguchi University. 2002.

31-  Abroun S, Ishikawa H, Tsuyama N, Liu S, Li F, Otsuyama K, Zheng X, Kawano M.M. Overexpression IL-6Ra to support myeloma cell survival. 99th Annual Scientific meeting of Yamaguchi University. 2002.

32-  Ishikawa H, Tsuyama N, Liu S, Abroun S, Li F, Otsuyama K, Kawano M.M. Consequence of FGFR3 overexpression on myeloma cell proliferation by IL-6. 64th Annual meeting of Japan society of Hematology and 44th Annual meting of Japan society of clinical hematology 2002.

33-  Li F, Tsuyama N, Otsuyama K, Ishikawa H, Liu S, Abroun S, Kawano M.M. Visualization of IL-6 signaling molecules by recombination with GFP-tag.64th Annual meeting of Japan society of Hematology and 44th Annual meting of Japan society of clinical hematology 2002.

34-  Liu S, Ishikawa H, Tsuyama N, Abroun S, Li F, Otsuyama K, Kawano M.M. Investigation of gene-expression of U266 myeloma cell line with or without CD45 expression.64th Annual meting of Japan society of Hematology and 44th Annual meeting of Japan society of clinical hematology 2002.

35-  Abroun S, Ishikawa H, Tsuyama N, Liu S, Li F, Otsuyama K, Kawano M.M. Anti-apoptotic effects of IL-6Ra overexpression on myeloma cells.64th Annual meting of Japan society of Hematology and 44th Annual meting of Japan society of clinical hematology 2002.

36-  Liu S, Ishikawa H, Tsuyama N, Abroun S, Li F, Kawano M.M. Gene expression in CD45+ U266 myeloma cell. 26th Annual myeloma meeting. 2001

37-  Li F, Tsuyama N, Ishikawa H, Abroun S, Liu S, Kawano M.M. GFP-tag used for IL-6 signals. 26th Annual myeloma meeting. 2001

38-  Ishikawa H, Tsuyama N, Abroun S, Liu S, Li F, Kawano M.M. Lyn is active by IL-6 stimulation in CD45+ myeloma cell. 26th Annual myeloma meeting. 2001

39-  Abroun S, Ishikawa H, Tsuyama N, Liu S, Li F, Kawano M.M. Insulin and IGF-I support myeloma cell proliferation. 26th Annual myeloma meeting. 2001

40-  Li F, Ishikawa H, Abroun S, Liu S, Kawano M.M. Establishment myeloma cell line that expresses MPC-1 antigen by IL-6. International Journal of Hematology, Vol. 73, Supplement No.1, 2001.

41-  Liu S, Ishikawa H, Abroun S, Li F, Kawano M.M. search for gene selectively expressed in CD45+U266. International Journal of Hematology, Vol. 73, Supplement No.1, 2001.

42-  Abroun S, Ishikawa H, Liu S, Li F, Kawano M.M. Mechanisms of myeloma cell survival supported by insulin or IGF-I. International Journal of Hematology, Vol. 73, Supplement No.1, 2001.

43-  Ishikawa H, Abroun S, Liu S, Kawano M.M. Src family kinase are essential for U266 CD45+ cell proliferation. The Japanese Journal of clinical Hematology. Vol.41 No.10, 2000

44-  Liu S, Ishikawa H, Abroun S, Kawano M.M. Growth character of immature myeloma cell in SCID-hIL-6 transgenic mice. The Japanese Journal of clinical Hematology. Vol.41 No.10, 2000.

45-  Abroun S, Ishikawa H, Liu S, Kawano M.M. Search for factors to support survival of myeloma cells in vitro. The Japanese Journal of clinical Hematology. Vol.41 No.10, 2000.

46-  Ishikawa H, Fuji R, Abroun S, Kawano M.M. Activation of Lyn Kinas in CD45+ cell proliferation enhanced by IL-6. International Journal of Hematology, Vol. 71, Supplement No.1, 2000.

47- Abroun S, Ishikawa H, Fuji R, Kawano M.M. The effect of IGF-I on survival of myeloma cells. International Journal of Hematology, Vol. 71, Supplement No.1, 2000



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